Chloroform 99% for HPLC & Spectroscopy 2.5L

Chloroform 99% HPLC – Identification of Product
Chemical Code: HPLC-C1
Chemical Name: Chloroform
Chemical Grade: HPLC
Chemical Formula: CHCl₃
Chemical Weight: 119,38 g/mol
CAS No: 67-66-3
Chemical Synonyms: Trichloromethane Methylidyne Trichloride

Chloroform 99% HPLC – Hazards Identification
REACH No: No Data Available
Signal Word: Danger
Supplemental Hazard Information:
Additional Hazard Information: This substance contains no components considered to be either persistent, bio-accumulative and toxic (PBT), or very persistent and very bio-accumulative (vPvB) at levels of 0.1% or higher.

Chloroform 99% HPLC – Hazards statements
H302 – Harmful if swallowed.
H315 – Causes skin irritation.
H319 – Causes serious eye irritation.
H331 – Toxic if inhaled.
H336 – May cause drowsiness or dizziness.
H351 – Suspected of causing cancer.
H361d – Suspected of damaging the unborn child.
H372 – Causes damage to organs through prolonged or repeated exposure.

Chloroform 99% HPLC – Precautionary statements
P261 – Avoid breathing vapours.
P281 – Use personal protective equipment as required.
P305 + P351 + P338 – IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P311 – Call a POISON CENTER or doctor/ physician.

Chloroform 99% HPLC – Composition of Chemical
Chemical Formula: CHCl₃
EC No 1272/2008: No Data Available

Chloroform 99% HPLC – First Aid Measures
General Advice: Consult a physician. Show this safety data sheet to the doctor in attendance.
If: Inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
If: Skin Contact: Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
If: Eye Contac: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If: Swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Important Symptoms: The most important known symptoms and effects are described in the labeling section.
Immediate Medical Attention: No Data Available

Chloroform 99% HPLC – Firefighting Measures
Extinguishing Media: Use Water spray, Alcohol-resistant foam, Dry chemical or Carbon Dioxide.
Hazards Arising: Carbon Oxides, Hydrogen Chloride gas
Advice for Firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
Info for Firefighting: No Data AvailableAccidental Release Measures
Personal Precautions: Wear respiratory protection.
Avoid breathing vapours, mist or gas.
Ensure adequate ventilation.
Evacuate personnel to safe areas.
Enviromental Precautions: Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Method for Containment: Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and Storage
Personal Precautions: Avoid contact with skin and eyes.
Avoid inhalation of vapour or mist.
Enviromental Precautions: Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
Exposure Controls | Personal Protection
Derived No Effect Level (DNEL)
Workers | Application Area | Exposure Routes | Health Effect | Value
No Data Available
Consumers | Application Area | Exposure Routes | Health Effect | Value
No Data Available
Predicted No Effect Concentration (PNEC)
No Data Available
Engineering Controls: No Data Available
Eye/Face Protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin Protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching gloves outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU
Directive 89/686/EEC and the standard EN 374 derived from it.Full contact –
Material: Fluorinated rubber. Minimum layer thickness: 0,7 mm
Break through time: 480 min. Material tested: Vitoject®.
Splash contact –
Material: Fluorinated rubber. Minimum layer thickness: 0,7 mm
Break through time: 480 min. Material tested: Vitoject®.
Data source: KCL GmbH, D-36124. Test method: EN374.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection: Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory Protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Physical and Chemical Properties
Appearance: Colourless, highly refractive liquid
Odour: Characteristic Odour
Odour Threshold: No Data Available
pH: No Data Available
Melting Point: Melting point/range: -63 °C
Boiling Point: 60,5 – 61,5 °C
Flash Point: No Data Available
Evaporation: No Data Available
Flammability: No Data Available
Upper/Lower Flammability or Explosive Limits: No Data Available
Vapour pressure: 213,3 hPa ( 20,0 °C)
Vapour density: No Data Available
Relative density: 1,492 g/mL ( 25 °C)
Water solubility: No Data Available
Partition Coefficien: log Pow: 1,97Auto-ignition Temperature: No Data Available
Decomposition Temperature: No Data Available
Viscosity: No Data Available
Explosive properties: No Data Available
Oxidizing properties: No Data Available
Other Safety Info: Surface tension: 27,1 mN/m ( 20,0 °C)

Stability and Reactivity
Reactivity: No Data Available
Chemical Stability: Stable under recommended storage conditions.
Possibility of hazardous reactions: No Data Available
Conditions to Avoid: No Data Available
Incompatible Materials: Strong oxidizing agents, Strong bases, Magnesium, Sodium/Sodium Oxides, Lithium
Hazardous Decomposition Products: No Data Available

Toxicological Information
Acute Toxicity: LD50 Oral – Rat – 908 mg/kg
Remarks: Behavioral: Change in motor activity (specific assay). Behavioral: Ataxia. Lungs, Thorax, or Respiration: Respiratory stimulation.
LOEC Inhalation – Rat – male – 6 h – 500 ppm
LD50 Dermal – Rabbit – > 20.000 mg/kg
Skin Corrosion/Irritation: Rabbit
Result: Irritating to skin. – 24 h
Serious Eye damage | Eye Irritation: Rabbit
Result: Irritating to eyes. – 24 h
Cell Mutagenicity: Laboratory experiments have shown mutagenic effects.
Carcinogenicity: Carcinogenicity – Rat – Oral
Tumorigenic:Carcinogenic by RTECS criteria. Leukaemia
The National Cancer Institute (NCI) has found clear evidence for carcinogenicity. Limited evidence of a carcinogenic effect.
IARC: 2B – Group 2B: Possibly carcinogenic to humans (Chloroform)
Reproductive toxicity: Suspected of damaging the unborn child.
Suspected human reproductive toxicant
Specific Target Organ Toxicity – Single Exposure: May cause drowsiness or dizziness.
Specific Target Organ Toxicity – Repeated Exposure: The substance or mixture is classified as specific target organ toxicant, repeated exposure, category 1. – Liver, KidneyAspiration Hazard: No Data Available

Ecological Information
Ecological Toxicity: Toxicity to fish:
LC50 – Leuciscus idus (Golden orfe) – 162 mg/l – 48 h,
LC100 – Leuciscus idus (Golden orfe) – 220 mg/l – 48 h,
LC50 – other fish – 97 mg/l – 96 h,
LC50 – Danio rerio (zebra fish) – 121 mg/l – 96 h,
NOEC – Oryzias latipes – 122 mg/l – 10 d,
NOEC – Oncorhynchus mykiss (rainbow trout) – 24 mg/l – 96 h.
Toxicity to daphnia and other aquatic invertebrates:
EC50 – Daphnia magna (Water flea) – 79,00 mg/l – 24 h.
Immobilization:
EC50 – Daphnia magna (Water flea) – 51,6 mg/l – 48 h,
NOEC – Daphnia magna (Water flea) – 120 mg/l – 11 d.
Toxicity to algae:
EC50 – No information available. – 500,00 mg/l – 24 h
Ecological Persistence and degradability: No Data Available
Bioaccumulative Potential: Bio-accumulation: Lepomis macrochirus (Bluegill) – 14 d – 0,11 mg/l
Bio-concentration factor (BCF): 6
Mobility in Soil: No Data Available
Results of PBT and vPvB Assessment: This substance contains no components considered to be either persistent, bio-accumulative and toxic (PBT), or very persistent and very bio-accumulative (vPvB) at levels of 0.1% or higher.
Other Adverse Effect: Harmful to aquatic life.

Disposal Considerations
Waste Treatment Methods: Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging – Dispose of as unused product.

Transport Information
UN Number: ADR/RID: 1888
IMDG: 1888
IATA: 1888
UN Shipping Hazard: ADR/RID: CHLOROFORMIMDG: CHLOROFORM
IATA: Chloroform
Transport Hazard Class: ADR/RID: 6.1
IMDG: 6.1
IATA: 6.1
Packaging Group: ADR/RID: III
IMDG: III
IATA: III
Enviromental Hazards: ADR/RID: no
IMDG Marine pollutant: no
IATA: no
Special Precautions: No Data Available

Regulatory Information
Safety, Health and environmental regulations: This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Chemical Safety Assessment: For this product a chemical safety assessment was not carried out.
Additional Info: RTECS: FS9100000
Vomiting, Gastrointestinal disturbance.
Exposure to and/or consumption of alcohol may increase toxic effects.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Disclaimer
The information stated above is considered to be correct, but does not claim to be inclusive and shall only be used as a guideline. The information provided by this document is confirmed by our continuous updating of knowledge and adheres to the products appropriate safety precautions. It does not represent any guarantee of the product’s
properties. RLS Chemicals and its Associates shall not be held accountable for any damage’s consequent of handling the above product

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